Glossarbegriff: Beclin-1

Protein BECN1 PDB 2p1l.png

Beclin-1 is a protein that in humans is encoded by the BECN1 gene.[5][6]Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6)  and BEC-1 in the C. elegans nematode.[7] This protein interacts with either BCL-2 or PI3k class III, playing a critical role in the regulation of both autophagy and cell death.

Role in disease

Beclin-1 plays an important role in tumorigenesis, and neurodegeneration, being implicated in the autophagic programmed cell death.[8] Ovarian cancerwith upregulated autophagy has a less aggressive behavior and is more responsive to chemotherapy.[9]

Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagy which in turn results in increased neuronal cell death.[10]


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