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“Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) is a protein that in humans is encoded by the MAP1LC3B gene.[5]LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes.[6]
Contents
- 1Discovery
- 2Function
- 3Structure
- 4Post-translational regulation
- 5References
- 6Further reading
Discovery
LC3 was originally identified as a microtubule associated protein in rat brain.[7] However it was later found that the primary function of LC3 is in autophagy, a process that involves the bulk degradation of cytoplasmic components.
Stand vom … ” → Wp
Synonyme:
LC3, LC3-II,
